茶碱经微处理机程序输注迅速达到期望兔血浆稳态水平(英文)

• 作 者: 段世明 徐迅 叶妙 傅英
• 机 构: 徐州医学院麻醉学系药理教研室,徐州医学院麻醉学系药理教研室,徐州医学院麻醉学系药理教研室,徐州医学院麻醉学系药理教研室 徐州 221002 中国,徐州 221002 中国,徐州 221002 中国,徐
• 出 处: Acta Pharmacologica Sinica
• 发表日期: 1994年05期
• 关键词: 茶碱药物动力学 血药浓度 兔血 用药计划表 输注速率 药物动力学 二室模型 infusion 输液泵 辅助药物

自制二室模型药物程序输液泵。向控制器输入兔茶碱药物动力学参数,期望血浆稳态浓度(C_(pss)),体重及时间。输注速率(K_t)=C_(pss)K_(10)V_cwt{1+[(K_(21)-β)/β]EXP(-K_(21)t)},血药浓度预报式为C_((t))=C_(pss)(1-e~(-αt)),依据显示配药液,自动输注。比色法测定血药浓度。96％的执行百分误小于±30％,其绝对值的中位数为8.3％。虽然T_2~1β=6.08h,但输注后30min(5T_2~1α),血药浓度达期望C_(pss)。

Homemade two-compartment model drug program infusion pump. Rabbit theophylline pharmacokinetic parameters were input to the controller, and the steady-state plasma concentration (C_ (pss)), body weight and time were expected. The infusion rate (K_t) = C_ (pss) K_ (10) V_cwt {1 + [(K_ (21) -β) / β] EXP (-K_ (21) t) (t)) = C_ (pss) (1-e ~ (-αt)), according to the display solution, automatic infusion. Colorimetric determination of plasma concentration. 96% of the implementation of the percentage error less than ± 30%, the absolute value of the median was 8.3%. Although T_2 ~ 1β = 6.08h, 30min after infusion (5T_2 ~ 1α), the plasma concentration reached the expectation of C_ (pss).