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目的在记忆障碍模型大鼠下,对比分析单体(西伯利亚远志糖A5和西伯利亚远志糖A6)、单味药(远志)和复方(开心散)3个层次的药动学特性及其相互作用性(PK-DI),考量远志与复方在治疗痴呆中的药物属性。方法采用HPLC-PDA同时测定给药后记忆障碍模型大鼠体内西伯利亚远志糖A5和西伯利亚远志糖A6血药浓度,获得各药物体内药代动力学表征数据,kinetics4.4软件处理数据。采用PK-DI关联分析法对比分析不同药物形式的特性表征。结果西伯利亚远志糖A5和西伯利亚远志糖A6药-时曲线均使用非房室模型处理。远志和开心散药代动力学表征相似,均呈现双峰吸收,而西伯利亚远志糖A5和西伯利亚远志糖A6单体药代动力学表征发生明显改变,呈单峰吸收。西伯利亚远志糖A5和西伯利亚远志糖A6的AUC值在远志组和开心散组间无明显差异,均远远大于单体组(P<0.01)。而与单味药远志相比,开心散复方药物状态下的最大血药浓度大幅增加(P<0.05)。结论与单体相比,单味药远志和开心散复方的药代动力学表征发生了改变,生物利用度大幅提高,且复方配伍后更是增大了药物作用强度,表征出复方药物协同作用特性,从而展示出了复方具有其药物属性特性。
OBJECTIVE To compare and analyze the pharmacokinetic characteristics and the interplay between three groups (Polygalaceae Siberian Polygala and Siberian Polygala A6), single drug (Polygalaceae) and Compound (Kaixin San) in rats with memory impairment (PK-DI), consider Polygalaceae and compound in the treatment of dementia in the drug properties. Methods HPLC-PDA was used to determine the plasma concentration of Siberian Polygala and Alzheimer’s disease A6 in rats with memory impairment at the same time. Pharmacokinetic characterization data of each drug were obtained and kinetics4.4 software was used to process the data. PK-DI correlation analysis was used to compare the characterization of different drug forms. Results Both Siberian Polygalaceae A5 and Siberian Polygala GT6 drug-time curves were treated with a non-compartmental model. Polygalaceae and Kaixin powder have similar pharmacokinetic characterization, showing bimodal absorption. However, the pharmacokinetic characterization of Polygala tenuifolia sibiricum A5 and Siberian polygala tenuifonose A6 significantly changed with single peak absorption. There was no significant difference in the AUC between the Polygalaceae Siberian Polygalaceae A5 and the Siberian Polygalaceous A6 in both Polygalaecta and Kaixin San, which were much larger than those in Monomer group (P <0.01). However, compared with single drug Polygalaceae, the maximal plasma concentration of Kaixin San compound drug significantly increased (P <0.05). Conclusion Compared with the monomer, the pharmacokinetics of single drug Polygalaceae and Kaixintan Compound have changed, the bioavailability has been greatly increased, and the drug combination has been strengthened after the combination of compound prescription, indicating the synergistic effect of compound drugs Characteristics, thus demonstrating that the compound has its own medicinal properties.