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目的:探讨异甘草酸镁对药物性肝炎患者的临床疗效以及对血清学指标的影响。方法:选取2013年4月—2015年9月间收治的药物性肝炎患者68例,将其随机分为观察组和对照组,每组34例;对照组患者给予甘草酸二铵治疗,观察组患者给予异甘草酸镁治疗,比较两组患者连续治疗14 d时的总有效率、血清学指标以及不良反应的发生情况。结果:观察组患者治疗后的总有效率显著高于对照组(97.06%vs 76.47%,P<0.05);治疗后观察组患者ALT、AST、TBIL、γ-GT和ALP水平均显著低于对照组(P<0.05);两组患者均无严重不良反应发生(P>0.05)。结论:异甘草酸镁用于治疗药物性肝炎患者的疗效较好,ALT下降迅速,安全性高,优于甘草酸二铵的疗效。
Objective: To investigate the clinical efficacy of magnesium isoglycyrrhizinate in patients with drug-induced hepatitis and its effect on serological parameters. Methods: A total of 68 patients with drug-induced hepatitis were selected from April 2013 to September 2015. They were randomly divided into observation group and control group, 34 cases in each group. Patients in the control group received diammonium glycyrrhizinate, Patients were given magnesium isoglycyrrhizinate. The total effective rate, serological parameters and adverse reactions of the two groups were compared after 14 days of continuous treatment. Results: The total effective rate of observation group was significantly higher than that of control group (97.06% vs 76.47%, P <0.05). After treatment, the levels of ALT, AST, TBIL, γ-GT and ALP in observation group were significantly lower than those in control group Group (P <0.05). No serious adverse reactions occurred in both groups (P> 0.05). Conclusion: Magnesium isobacyx glycyrrhizinate is effective in the treatment of patients with drug-induced hepatitis. ALT decreased rapidly and safely, which is superior to that of diammonium glycyrrhizinate.