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目的观察雾化吸入前列腺I(2PGI2)对急性呼吸窘迫综合征(ARDS)患者血流动力学、动脉血气、氧合状况的影响,评价其治疗效果。方法2006年11月～2008年12月共救治ARDS患者55例,随机分为PGI2治疗组(28例)和对照组(27例)。治疗组在入院24h后雾化吸入PGI230ng/kg·min,每次25min,每天10次,连续使用7d。从血流动力学变化、动脉血氧分压(PaO2)、呼吸机通气时间及生存率等方面进行比较。结果治疗组PaO2、Pa02/FiO2恢复时间较对照组早(P<0.01,P<0.05),呼吸机支持时间显著短于对照组(P<0.01),生存率显著高于对照组(P<0.05)。结论PGI2能有效降低肺动脉压和肺血管阻力,增加心排量和氧供,提高其生存率,对ARDS有较好疗。
Objective To observe the effects of nebulized prostatic I (2PGI2) on hemodynamics, arterial blood gas and oxygenation in patients with acute respiratory distress syndrome (ARDS) and to evaluate its therapeutic effect. Methods From November 2006 to December 2008, 55 patients with ARDS were randomly divided into PGI2 treatment group (n = 28) and control group (n = 27). In the treatment group, the PGI230ng / kg · min was inhaled 24 hours after admission, each time 25min, 10 times a day for 7 days. From hemodynamic changes, arterial partial pressure of oxygen (PaO2), ventilator ventilation time and survival rates compared. Results The recovery time of PaO2 and PaO2 / FiO2 in the treatment group was earlier than that in the control group (P <0.01, P <0.05) and the support time of the ventilator was significantly shorter than that in the control group (P <0.01), and the survival rate was significantly higher than that in the control group ). Conclusions PGI2 can effectively reduce pulmonary arterial pressure and pulmonary vascular resistance, increase cardiac output and oxygen supply, improve its survival rate and have better therapeutic effect on ARDS.