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目的探讨乳腺癌组织中P27蛋白和血管内皮生长因子(VEGF)的表达意义,及其与乳腺癌病理类型的相关性。方法分析2010年5月至2013年9月接受手术治疗的60例乳腺癌患者(乳腺癌组织)的临床资料和病理标本,另选取30例正常乳腺组织标本作为对照(正常乳腺组织)。比较乳腺癌组织和正常乳腺组织中P27蛋白和VEGF的阳性表达率,以及P27蛋白和VEGF表达水平与病理类型的相关性。结果乳腺癌组织中VEGF的阳性表达率高于正常乳腺组织(P<0.01),而P27蛋白的阳性表达率明显低于正常乳腺组织(P<0.01)。不同病理类型标本中P27蛋白(P=0.76)和VEGF的阳性表达率差异无统计学意义(均P>0.05)。结论乳腺癌组织中VEGF水平显著高于正常乳腺组织,P27蛋白表达水平显著下降,且P27蛋白和VEGF的表达与乳腺癌病理分型无关。
Objective To investigate the expression of P27 protein and vascular endothelial growth factor (VEGF) in breast cancer and its correlation with pathological types of breast cancer. Methods The clinical data and pathological specimens of 60 patients with breast cancer (breast cancer) who underwent surgery from May 2010 to September 2013 were analyzed. Thirty normal breast tissues were selected as control (normal breast tissue). The positive rates of P27 protein and VEGF in breast cancer tissues and normal breast tissues were compared, and the correlation between the expression of P27 protein and VEGF and pathological types was also analyzed. Results The positive rate of VEGF in breast cancer tissues was higher than that in normal breast tissues (P <0.01), while the positive rate of P27 protein was significantly lower than that in normal breast tissues (P <0.01). There was no significant difference in the positive rates of P27 protein (P = 0.76) and VEGF between different pathological types (all P> 0.05). Conclusion The VEGF level in breast cancer tissues is significantly higher than that in normal breast tissues, the expression of P27 protein is significantly decreased, and the expression of P27 protein and VEGF is not related to the pathological type of breast cancer.