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1984年,对1557名9～20岁女学生进行风疹抗体筛检,631人抗体阴性,对其中442名志愿者接种了风疹RA 27/3株减毒活疫苗。接种量为0.5ml,含1000半数组织培养感染量(TCID_(50))。于接种后1～2周、4～5周、1年和2年采血检测血凝抑制抗体,血清阳转率分别为16.9%、99.7%、100%和100%。血清阳转者的抗体几何平均滴度(GMT)分别为40、406、364和305。抗体出现时间大多在接种后1～2周,接种后7天有15%的接种者出现抗体应答;接种后4～5周,除1人外(此人于接种后1
In 1984, 1557 female students aged 9-20 years were screened for rubella antibody, 631 were negative, and 442 volunteers were immunized with 27/3 attenuated live attenuated RA vaccine. Inoculation volume of 0.5ml, containing 1000 half of tissue culture infection (TCID_ (50)). After 1, 2, 4, 5, 1 and 2 years after inoculation, the hemagglutination inhibition antibodies were detected. The seroconversion rates were 16.9%, 99.7%, 100% and 100% respectively. Antibody geometric mean titers (GMTs) of seroconverters were 40, 406, 364 and 305, respectively. Most of the antibody appeared in 1 ~ 2 weeks after inoculation, and 15% in 7 days after inoculation showed antibody response. In 4 ~ 5 weeks after inoculation, except 1,