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目的探讨江西地区女性宫颈癌前病变及宫颈癌患者人乳头瘤病毒(HPV)主要感染型别。方法选取2015年1-12月该院肿瘤科住院患者为研究对象。采用导流杂交技术对宫颈癌前病变患者667例和宫颈癌患者394例进行HPV感染型别检测,并对不同级别的癌前病变及不同病理类型宫颈癌型别感染情况进行分析。结果宫颈癌前病变及宫颈癌中以单一HPV感染为主。宫颈癌前病变组织中总HPV感染率为90.4%,主要感染型别依次为HPV16、58、52、33、31和51;宫颈癌组织中总HPV感染率为97.5%,主要感染型别依次为HPV16、18、52和58。不同级别的宫颈癌前病变HPV感染率比较差异无统计学意义(χ~2=4.574,P=0.102),但随着级别升高,HPV16、18型感染也升高(χ~2=42.700,P=0.000)。不同病理类型的宫颈癌HPV感染率比较差异有统计学意义(χ~2=8.799,P=0.012)结论江西地区中HPV16、58、52、33、31、51型别为宫颈癌前病变中的主导型别,HPV16、18、52、58型别为宫颈癌中主导型别,HPV16、18型感染提示宫颈癌变高风险存在。
Objective To investigate the prevalence of human papillomavirus (HPV) in women with cervical precancerous lesions and cervical cancer in Jiangxi Province. Methods From January to December in 2015, the inpatients of oncology department in this hospital were selected as the research object. Sixty-seven cases of cervical precancerous lesions and 394 cases of cervical cancer were tested for HPV infection by flow-through hybridization. The infection of different grades of precancerous lesions and different types of cervical cancer were analyzed. Results Cervical precancerous lesions and cervical cancer were mainly single HPV infection. The total HPV infection rate in premalignant cervical lesions was 90.4%. The main infection types were HPV16,58,52,33,31 and 51. The total HPV infection rate in cervical cancer was 97.5%. The main infection types were HPV 16, 18, 52 and 58. HPV infection rates of cervical precancerous lesions at different grades had no significant difference (χ ~ 2 = 4.574, P = 0.102), but HPV16,18 infection was also increased with the increasing of grade (χ ~ 2 = 42.700, P = 0.000). There were significant differences in HPV infection rates between different pathological types of cervical cancer (χ ~ 2 = 8.799, P = 0.012) .Conclusion The HPV16,58,52,33,31,51 types in Jiangxi province are the most common type of cervical precancerous lesions Leading type, HPV16,18,52,58 type is the leading type of cervical cancer, HPV16,18 infection prompted cervical cancer there is a high risk.