论文部分内容阅读
目的:探讨妊娠期高血压患者血浆脑钠肽浓度与新生儿预后的关系。方法:80例妊娠期高血压性不同程度的心衰患者及80例正常健康孕妇对照组进行血清BNP检测,同时对两组产后的新生儿窒息率进行分析比较,探讨妊娠期高血压患者血浆脑钠肽浓度与新生儿预后的关系。结果:BNP<40 pg/L的患者都为心功能I级,41~80 pg/L的患者都为心功能II级,81~115 pg/L的患者都为心功能Ⅲ级。正常对照组全部BNP<40 pg/L。妊娠期高血压性心衰组与对照组新生儿窒息率比较差异有统计学意义(P<0.01),不同BNP含量的妊娠期高血压性心衰间相比较新生儿窒息率差异也有统计学意义(P<0.01)。结论:妊娠期高血压患者血浆脑钠肽浓度与妊娠期高血压性心衰心功能分级成正相关,心功能分级的增加导致新生儿窒息发生率增加。妊娠期高血压患者血浆脑钠肽浓度与新生儿预后密切相关。
Objective: To investigate the relationship between the concentration of plasma brain natriuretic peptide and the prognosis of newborn in hypertensive patients during pregnancy. Methods: Serum BNP levels were measured in 80 pregnant women with different stages of pregnancy-induced hypertension and 80 healthy pregnant controls. At the same time, the incidence of postpartum asphyxia in both groups was analyzed and compared to explore the relationship between plasma brain Relationship between the concentration of natriuretic peptide and the prognosis of neonates. Results: Patients with BNP <40 pg / L had grade I heart function, patients with grade 41 to 80 pg / L had grade II heart function, and patients with grade 81 to 115 pg / L had grade III heart function. The normal control group all BNP <40 pg / L. Compared with neonatal asphyxia rate in gestational hypertensive heart failure group and control group, the difference was statistically significant (P <0.01). Compared with neonatal asphyxia rate in gestational hypertensive heart failure with different BNP content, the difference was also statistically significant (P <0.01). CONCLUSION: Plasma BNP concentration in patients with gestational hypertension is positively correlated with the grading of cardiac function in hypertensive heart failure during pregnancy. Increased cardiac function results in an increased incidence of neonatal asphyxia. The concentration of plasma brain natriuretic peptide in patients with gestational hypertension is closely related to the prognosis of neonates.