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目的评价室间隔化学消融术治疗肥厚梗阻型心肌病在急性期的效果。方法对52例确诊肥厚梗阻型心肌病患者进行经皮室间隔化学消融术治疗,并于术前、术后急性期进行超声心动观察。结果41例患者介入治疗成功,成功率为78.8%。术前超声观察室间隔平均厚度(22.96±5.15)mm,左室流出道压力阶差(LVOTPG)(92.64±38.69)mm Hg(1mm Hg=0.133kPa),术后急性期(4.8±3.2)d,室间隔平均厚度(21.27±4.64)mm,较术前比变薄,P<0.05;LVOTPG(51.79±38.99)mm Hg,较术前明显降低,P<0.001。结论经皮室间隔化学消融术治疗肥厚梗阻型心肌病,在急性期可使室间隔平均厚度降低,收缩期左室流出道压力阶差显著下降。
Objective To evaluate the effect of interventricular septum ablation on hypertrophic obstructive cardiomyopathy in acute stage. Methods Fifty-two patients with hypertrophic obstructive cardiomyopathy were treated with transcatheter interventricular septum ablation, and echocardiography was performed preoperatively and postoperatively. Results 41 cases of successful intervention, the success rate was 78.8%. The mean interventricular septum thickness (22.96 ± 5.15) mm, LVOTPG (92.64 ± 38.69) mm Hg (1 mm Hg = 0.133 kPa) and postoperative acute 4.8 ± 3.2 d , Mean interventricular septum thickness was (21.27 ± 4.64) mm, thinner than preoperative, P <0.05; LVOTPG (51.79 ± 38.99) mm Hg was significantly lower than preoperatively, P <0.001. Conclusion percutaneous transluminal septal chemical ablation for hypertrophic obstructive cardiomyopathy in the acute phase can reduce the average thickness of interventricular septum, systolic left ventricular outflow tract pressure gradient decreased significantly.