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目的 :研究乙型肝炎表面抗原携带者及其子女间的遗传传递。方法 :对乙型肝炎表面抗原携带者 117个家庭 2 34个个体进行了 HBV五项血清标志物 (HBs Ag、抗 - HBs、HBe Ag、抗 - HBe和抗 - HBc)及游离型 HBV DNA检测。结果 :HBs Ag阳性父亲出生的子女与 HBs Ag阴性的父亲所生的子女相比 ,差异非常显著。在 HBs Ag父、子女同阳的 6 3个家系中 ,HBV血清学标志组合父、子女同时阳性率为 5 2 .4% ,其 HBV DNA主要分布在父、子女同阳组合中 ,与其他标志组合相比 ,有非常显著性差异。HBV DNA与 HBe Ag标志呈一致性增高 ,HBe Ag阳性父亲所生子女 HBe Ag和 HBV DNA也都阳性。HBs Ag高滴度的父亲 HBV DNA与出生后的子女呈一致性增高。结论 :HBs Ag阳性者 ,通过父亲遗传传递给子代是有可能的。
Objective: To study the genetic transmission of hepatitis B surface antigen carriers and their children. Methods: Five serum HBV markers (HBs Ag, anti - HBs, HBe Ag, anti - HBe and anti - HBc) and free HBV DNA were detected in 117 families and 235 carriers of hepatitis B surface antigen. . RESULTS: Children born to HBsAg-positive fathers were significantly different from those born to HBsAg-negative fathers. Among the 63 pedigrees of HBsAg and their children, the positive rate of HBV serology was 52.4% at the same time, and the HBV DNA was mainly distributed in the combination of father and child with other positive signs Compared with the combination, there is a very significant difference. HBV DNA and HBeAg markers were consistent increased, HBe Ag positive father born children HBeAg and HBV DNA are also positive. HBs Ag high titers of the father HBV DNA consistent with the increased birth of children. CONCLUSIONS: It is possible that HBsAg-positive individuals passed on to their offspring through their father’s inheritance.