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目的:雌激素具有心血管保护作用,但其不良效应限制了雌激素在防治心血管疾病方面的应用。寻求更有效、安全的雌激素替代品已成为心血管药物研究的热点。本文就植物性雌激素大豆异黄酮对心血管保护作用的研究现状进行综述。资料来源:应用计算机检索Medline1993-01/2001-12的相关文章,检索词“isoflavones,atherosclerosis,vasodilation”,并限定文章语言种类为English。同时计算机检索万方数据资源系统与中国期刊全文数据库1994-01/2002-02的文章,限定文章语言种类为中文,检索词“异黄酮类,动脉硬化,血管舒张”。资料选择:对资料进行初审,选取实验包括实验组和对照组的文献,筛除明显不随机实验的研究,对剩余的文献开始查找全文,进一步判断为随机对照实验。纳入标准为①随机对照实验,采用单盲,双盲或非盲法。②实验包含平行对照组。排除标准:排除重复性实验研究。资料提炼:共收集到31篇关于大豆异黄酮对心血管保护作用的随机和未随机实验文章,26个实验符合纳入标准。排除的5篇实验均为重复的同一研究。资料综合:26个实验包括临床实验和动物实验,分别给予大豆异黄酮后采用在体或离体两种实验方法,观察大豆异黄酮对心血管的保护作用,并对此给予评价。以上两种方法各有优缺点,其中以离体实验进行观察的方法较
Objective: Estrogen has cardiovascular protective effect, but its adverse effect limits the application of estrogen in the prevention and treatment of cardiovascular diseases. Seeking more effective and safe estrogen replacement has become a hot research topic in cardiovascular medicine. This review summarizes the current research status of phytoestrogen soy isoflavones on cardiovascular protection. Source: Application of computer-based retrieval of articles related to Medline1993-01 / 2001-12, the term “isoflavones, atherosclerosis, vasodilation” and the article language is limited to English. At the same time, the article of Wanfang Data Resource System and China Journals Full-text Database 1994-01 / 2002-02 was searched by computer, and the article language was limited to Chinese. The key words were isoflavones, arteriosclerosis and vasodilatation. Data Selection: The data were first reviewed, and the experimental data including the experimental group and the control group were selected to screen out the study which was obviously not randomized. The remaining documents were searched for the full text and further judged as randomized controlled experiments. Inclusion criteria for ① randomized controlled trials, using single-blind, double-blind or non-blind method. ② experiment contains parallel control group. Exclusion Criteria: Eliminate repetitive experimental studies. DATA EXTRACTION: A total of 31 randomized and non-randomized experimental articles on the cardiovascular protective effect of soy isoflavones were collected. Twenty-six experiments met the inclusion criteria. The five experiments that were excluded were all duplicates of the same study. Data synthesis: 26 experiments including clinical trials and animal experiments were given in vitro or in vivo after soy isoflavones were used in two ways to observe the protective effect of soy isoflavones on cardiovascular, and give evaluation. The above two methods have their own advantages and disadvantages, of which the method of in vitro experiments were compared