论文部分内容阅读
目的探讨肝动脉化疗栓塞术(TACE)对原发性肝癌患者T淋巴细胞亚群的影响。方法对2005年3月至2006年4月在我科行TACE的肝癌患者于治疗前1d、治疗后1周和2周分别测定外周血T细胞亚群,进行比较,同时采用健康志愿者作为对照组进行治疗前比较。结果治疗前CD3+、CD4+、CD4+/CD8+水平较对照组显著降低,治疗后1周CD3+、CD4+、CD4+/CD8+水平均较治疗前略升高,但差异无统计学意义。治疗后2周CD3+、CD4+、CD4+/CD8+水平均较治疗前显著升高。结论肝癌患者细胞免疫功能处于抑制状态,TACE对细胞免疫功能影响较小,随着肿瘤负荷减小,细胞免疫功能显著提高。
Objective To investigate the effect of transcatheter arterial chemoembolization (TACE) on T lymphocyte subsets in patients with primary liver cancer. Methods From March 2005 to April 2006, T lymphocyte subsets in peripheral blood were measured at 1 d before treatment, 1 week and 2 weeks after TACE treatment in our hospital, and compared with healthy volunteers at the same time Group before treatment comparison. Results The levels of CD3 +, CD4 + and CD4 + / CD8 + before treatment were significantly lower than those in the control group. The levels of CD3 +, CD4 + and CD4 + / CD8 + in the first week after treatment were slightly higher than those before treatment, but the difference was not statistically significant. The levels of CD3 +, CD4 +, CD4 + / CD8 + in two weeks after treatment were significantly higher than those before treatment. Conclusion The cellular immune function of HCC patients is in a state of inhibition. TACE has little effect on cellular immune function. With the decrease of tumor burden, cellular immune function is significantly increased.