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类风湿关节炎(rheumatoid arthritis,RA)是一种主要累及全身多关节的自身免疫性疾病。目前RA仍具有很高的关节致残率和病死率。早期诊断并进行积极治疗可有效减少关节畸形的可能。近年发现的抗瓜氨酸抗体(anti-citrullinated peptide anti-bodies,ACPA)可在关节破坏发生前即表现出阳性,该抗体与经典的类风湿因子(rheumatoid factor,RF)相比,在RA的诊断中具有相似的敏感性,但具有更高的特异性。研究发现抗环瓜氨酸抗体(anti-cyclic citrullinated peptide antibodies)在RA的早期诊断、预后判断等方面都有重要意义,并有流行病学证据显示其可能在RA的发病中扮演重要角色。
Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the whole body and polyarthrosis. Currently RA still has a high degree of joint disability and mortality. Early diagnosis and active treatment can effectively reduce the possibility of joint deformity. In recent years, anti-citrullinated peptide anti-bodies (ACPA) have been shown to be positive prior to the onset of joint disruption, compared with the classic rheumatoid factor (RF) There is similar sensitivity in diagnosis, but with higher specificity. It has been found that anti-cyclic citrullinated peptide antibodies are important in the early diagnosis and prognosis of RA, and epidemiological evidence suggests that it may play an important role in the pathogenesis of RA.