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目的观察三黄煎剂改善乳腺癌围手术期患者炎症反应临床功效,探讨其降低肿瘤复发转移的相关关系。方法将2015年4月至12月在江苏省中医院乳腺外科住院治疗的30例乳腺癌患者,随机分为治疗组与对照组,每组各15例。对照组予以基础治疗,实验组在基础治疗同时于术前1日起至术后第7天,每日口服三黄煎剂一剂,分早晚各服1次,两组分别于手术当日和术后第1天、第3天、第7天评估中医症状与炎症症状积分,酶联免疫吸附试验(ELISA)法测定血清炎症相关指标白介素(IL)-2R、IL-6、IL-8、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平。结果治疗组中医症状积分与炎症积分于术后第3天显著改善,与对照组相比,有统计学差异(P<0.05)。两组血清中炎症指标术后第1天均显著上升,治疗组术后第3天即显著下降,第7天恢复至术前水平,对照组术后7天仍显著高于术前,术后第3天、第7天治疗组血清炎症指标显著低于对照组,差异有统计学意义(P<0.05,P<0.01)。结论三黄煎剂可有效改善术后中医临床症状与炎症表现,显著降低乳腺癌围手术期患者血清炎症水平,有利于降低复发转移的风险。
Objective To observe the clinical efficacy of sanhuang decoction in improving perioperative inflammatory response in patients with breast cancer and to explore its relationship to reduce the recurrence and metastasis of breast cancer. Methods Thirty cases of breast cancer hospitalized in Department of Breast Surgery, Jiangsu Provincial Hospital of Traditional Chinese Medicine from April 2015 to December 2015 were randomly divided into treatment group and control group, with 15 cases in each group. In the control group, basic treatment was given. In the experimental group, basal treatment was performed on the 1st day before surgery to the 7th day after the operation. One dose of Sanhuang decoction was administered daily, one morning and one night, The scores of TCM symptoms and inflammatory symptoms were evaluated on the 1st day, the 3rd day and the 7th day. Serum IL-2R, IL-6, IL-8 and tumor markers were detected by enzyme linked immunosorbent assay (ELISA) Necrosis factor-α (TNF-α), C-reactive protein (CRP) levels. Results The scores of TCM symptom score and inflammation score in the treatment group were significantly improved on the 3rd day after operation, which were significantly different from those in the control group (P <0.05). Serum inflammatory markers in both groups were significantly increased on the first day after operation, the treatment group decreased significantly on the third day after operation, returned to the preoperative level on the seventh day, and remained significantly higher on the 7th day after operation in the control group On the third day and the seventh day, the index of serum inflammation in the treatment group was significantly lower than that in the control group (P <0.05, P <0.01). Conclusion Sanhuang decoction can effectively improve the clinical symptoms and inflammatory manifestations of postoperative Chinese medicine, and significantly reduce the level of serum inflammation in perioperative patients with breast cancer, which is beneficial to reduce the risk of recurrence and metastasis.