多发性骨髓瘤的肾脏损害11例报告

• 作 者: 崔志钧 周孟元 李彬
• 机 构: 大连医学院附属第一医院内科,大连医学院附属第一医院内科,大连医学院附属第一医院内科,
• 出 处: 大连医学院学报
• 发表日期: 1987年01期
• 关键词: 多发性骨髓瘤 肾脏 慢性肾炎型 全型 骨痛 血沉 肾功 肾功能 白细胞减少 早期诊断

本文报告了11例多发性骨髓瘤(MM)肾病。男性5例,女性6例,平均年龄58.3岁。表现四种临床类型,慢性肾炎型及慢性肾功不全型占80%。本文着重分析了MM肾病的临床表现。指出了典型的MM诊断并不困难,但以肾病为主的MM可能误诊。提出三点早期诊断线索:(1)成人40岁以上,原因不明的蛋白尿伴贫血或骨痛与血沉快。(2)贫血与肾功能不相称(3)白细胞减少。同时复习文献,对MM肾病的机制加以讨论。

This article reports 11 cases of multiple myeloma (MM) nephropathy. 5 males and 6 females, with an average age of 58.3 years. Performance of the four clinical types, chronic nephritis and chronic renal insufficiency accounted for 80%. This article focuses on the analysis of the clinical manifestations of MM nephropathy. Pointed out that the typical MM diagnosis is not difficult, but the kidney-based MM may be misdiagnosed. Put forward three early diagnosis clues: (1) adults over the age of 40, unexplained proteinuria with anemia or bone pain and ESR faster. (2) anemia and renal dysfunction (3) leukopenia. At the same time review the literature on the mechanism of MM nephropathy to be discussed.