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为探讨脐血 (cordblood ,CB)对急性髓系白血病 (ALL)强烈化疗后骨髓抑制期的辅助及支持治疗作用 ,用密闭式采血法采集CB ,一个胎盘所采集CB为 1个单位。对 42例AML患儿采用HAE/DAE方案化疗 ,其中治疗组在强烈化疗后 ,短期内多个CB连续输注 ,平均 4～ 5个单位CB。结果治疗组骨髓抑制期天数短于对照组 (P<0 .0 1 ) ,骨髓抑制程度治疗组较轻 ,治疗组血小板和中性粒细胞相对较高 (P <0 .0 1 ) ,并且治疗组感染和出血发生率低于对照组 (P <0 .0 1 )。另外 ,输注CB治疗组缓解率高于对照组 (P <0 .0 5 )。结果表明 ,CB输注对AML强化疗后的骨髓抑制有明显的恢复作用 ,可以减轻骨髓抑制程度 ,缩短骨髓抑制期 ,从而减少化疗后感染出血发生率 ,并有助于AML达到完全缓解 ,CB输注治疗白血病是一种有效的辅助及支持疗法 ,有其独特的临床应用价值
In order to investigate the effect of cord blood (CB) on adjuvant and supportive myelosuppression after acute chemotherapy in acute myeloid leukemia (ALL), CB was collected by closed blood sampling, and 1 CB was collected from one placenta. 42 cases of AML children with HAE / DAE regimen chemotherapy, which treatment group after intensive chemotherapy, short-term multiple CB continuous infusion, with an average of 4 to 5 units of CB. Results The number of days of myelosuppression in treatment group was shorter than that in control group (P <0.01). The degree of myelosuppression was lower in treatment group and the platelet and neutrophil count were higher in treatment group (P <0.01) The incidence of infection and bleeding was lower in the control group (P <0.01). In addition, the response rate of CB infusion group was higher than that of control group (P <0.05). The results showed that CB infusion had a significant effect on myelosuppression after AML chemotherapy and could reduce the degree of myelosuppression and shorten the period of myelosuppression so as to reduce the incidence of postoperative infection and help to achieve complete remission of AML. Infusion therapy leukemia is an effective adjuvant and supportive therapy, has its unique clinical value