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目的 观察晚期高位胆管癌患者的门静脉血流改变及其导致的肝功能变化情况。方法 对 13例术中活检确诊为晚期不能切除的高位胆管癌患者术前及术后 3个月分别行多普勒超声检查 ,检测门静脉血流情况 ,同时检测肝功能 ,了解门静脉血流改变及其所导致的肝功能变化情况。结果 晚期高位胆管癌患者的门静脉血流量明显低于正常人 (P <0 .0 0 1) ,而且随着时间的延长 ,病情不断加重 ,门静脉血流量减少 ,尽管经内引流后总胆红素不断下降甚至达到正常水平 ,但是因门静脉血供不足 ,肝脏功能不断恶化 ,白蛋白浓度明显降低 (P <0 .0 5 )。结论 晚期高位胆管癌患者的门静脉血流量明显低于正常 ,常导致低蛋白血症等营养不良表现。
Objective To observe the changes of portal vein blood flow and the changes of liver function in patients with advanced cholangiocarcinoma. Methods Thirteen patients with high cholangiocarcinoma who were diagnosed as unresectable advanced biopsies were examined with Doppler ultrasonography before operation and at 3 months after operation to detect the portal vein blood flow and to detect the liver function and to understand the changes of portal vein blood flow The resulting changes in liver function. Results The portal vein blood flow of patients with advanced cholangiocarcinoma was significantly lower than that of normal people (P <0.01), and with the prolongation of time, the condition was aggravated and the portal blood flow decreased. Although total bilirubin Continuously decreased or even reached the normal level, but due to insufficient portal vein blood supply, liver function deteriorated and albumin concentration was significantly decreased (P <0.05). Conclusions The portal venous flow in patients with advanced cholangiocarcinoma is significantly lower than normal and often leads to malnutrition such as hypoproteinemia.