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目的 :探讨缺氧性肺动脉高压新生乳猪肺血管形态学的变化。方法 :4 2只新生乳猪分成正常发育组和缺氧性肺动脉高压组。其中 2 0只新生乳猪置于低气压仓中 3或 11d形成不同程度缺氧性肺动脉高压模型。采用免疫组化方法和γ 肌动蛋白抗体染色对肺小动脉的形态学变化进行定量分析。结果 :正常新生乳猪出生后早期随着日龄增加 ,血管壁中层百分率快速下降 ;缺氧抑制了中层厚度百分率的下降 ,甚至增加这种百分率 (P <0 .0 1) ,同时中层与管腔面积比值与中层百分率有相同的变化倾向。结论 :新生乳猪出生后肺血管快速重构以适应子宫外生活环境。缺氧及缺氧性肺动脉高压改变正常肺血管的重构 ,导致或加重肺动脉高压
Objective: To investigate the changes of pulmonary vascular morphology in neonatal neonatal piglets with hypoxic pulmonary hypertension. Methods: 42 newly born piglets were divided into normal developmental group and hypoxic pulmonary hypertension group. 20 neonatal piglets were placed in the low-pressure storage 3 or 11d to form hypoxic pulmonary hypertension models. The morphological changes of pulmonary arterioles were quantitatively analyzed by immunohistochemistry and γ-actin antibody staining. Results: Normal neonatal suckling pigs rapidly decreased in the early postnatal period with the increase of the age. The hypoxia inhibited the decrease of middle thickness percentage and even increased the percentage (P <0.01) The cavity area ratio has the same tendency of change as the middle percentage. Conclusion: The neonatal piglets are rapidly reconstructed after birth to adapt to the uterine life environment. Hypoxia and hypoxic pulmonary hypertension alter normal pulmonary vascular remodeling, leading to or exacerbating pulmonary hypertension