论文部分内容阅读
医院药品不良反应监测是临床药学工作的一项重要内容,1998年我院临床药学工作人员参加了多次与药品不良反应相关的会诊,其中有2例病人因药品不良反应引起死亡,现报道如下。 例1,噻氯匹定(Ticlopidine)引起再生障碍性贫血。患者男,55岁,因患冠心病于1998年5月行“经皮冠状动脉球囊扩张术(PTCA)”。术后给予抗凝治疗,阿司匹林100mg/d,噻氯匹定250mg/次,bid。连续服药40余天后出现畏寒、发热、伴头昏、乏力、全身肌肉酸痛,于1998年6月14日急诊入院。入院时血常规显示全血细胞减少(WBC 0.6 ×10~9/L,RBC 2.97×10~(12)/L,PLT
Adverse drug reactions monitoring in hospitals is an important part of clinical pharmacy work. In 1998, clinical pharmacy staff in our hospital participated in many consultations related to adverse drug reactions. Among them, 2 patients died of adverse drug reactions and are reported as follows . Example 1 Ticlopidine causes aplastic anemia. Male, 55 years old, underwent coronary artery balloon dilatation (PTCA) in May 1998 due to coronary heart disease. After anticoagulant therapy, aspirin 100mg / d, ticlopidine 250mg / time, bid. Cholera, fever, accompanied by dizziness, fatigue, body aches and pains occurred after more than 40 days of continuous medication, and was admitted to the emergency department on June 14, 1998. Blood samples at admission showed pancytopenia (WBC 0.6 × 10 ~ 9 / L, RBC 2.97 × 10 ~ (12) / L, PLT