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目的研究血管紧张素转换酶（ＡＣＥ）基因插入／缺失多态性与ＩＣＶＤ的关系。方法应用聚合酶链式反应（ＰＣＲ）技术，对８８例缺血性脑血管病（ＩＣＶＤ）组患者和８２例对照组人群分别检测其基因频率和基因型频率。结果ＤＩ等位基因频率之比脑血管病组为０．５９０．４１，对照组为０．４２０．５８（Ｐ＜０．０５）；ＤＤ基因型在ＩＣＶＤ组更多见（３１／８８例），对照组１５／８２例（Ｐ＜０．０５）；ＤＤ基因型对各种类型ＩＣＶＤ的相对危险性为２．４３，进一步分析表明，其危险性增高主要是由腔隙性梗塞和脑栓塞所致。结论ＡＣＥ基因缺失多态性与ＩＣＶＤ的发生显著相关，ＡＣＥ基因的缺失多态性对腔隙性梗塞和脑栓塞均可能是独立的危险因素。
Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion / deletion polymorphism and ICVD. Methods Polymerase chain reaction (PCR) was used to detect the gene frequency and genotype frequency in 88 patients with ischemic cerebrovascular disease (ICVD) and 82 controls. Results The frequency of DI allele was 0.590.41 in cerebrovascular disease group and 0.420.58 in control group (P <0.05). DD genotype was more common in ICVD group (31/88 cases) , And 15/82 in control group (P <0.05). The relative risk of DD genotype to ICVD was 2.43. Further analysis showed that the increased risk was mainly caused by lacunar infarction and cerebral embolism Due. Conclusions ACE gene deletion polymorphism is significantly associated with the occurrence of ICVD. The deletion polymorphism of ACE gene may be an independent risk factor for lacunar infarction and cerebral embolism.