论文部分内容阅读
1994年夏选择疫区鄱阳湖边的星子县 2个自然村和恒湖农场的 1个自然村 ,按双盲配对设青蒿琥酯和安慰剂两组。剂量为 6mg/kg顿服 ,安慰剂形状、色泽、重量相同。每周服 1次 ,试验期共服药 8次于停止服药后 4周进行效果评价。粪检用Kato′s法加孵化。共考核服青蒿琥酯 2 2 6人 ,全部阴性。对照 (安慰剂组 )考核 179人 ,阳性率 14.5 %。服药组无 1例急性血吸虫病发生 ,对照组发生 3例。服药后询问 5 40 0人次 ,副反应出现率在 0 .4%以下 ;与对照组无差异。服药后血尿常规、肝、肾功能及心电图复查都在正常值范围内 ,与对照组比较也无差异。
In the summer of 1994, two natural villages in Xingzi County and one natural village in Henghu Farm were selected along the Poyang Lake in the affected area. Artesunate and placebo were double-blindly matched. Dose 6mg / kg Dayton clothing, placebo shape, color, weight the same. 1 week per week, a total of 8 times during the trial to stop taking medication after 4 weeks to evaluate the effect. Fecal seizures with Kato’s Act hatch. A total of examination of service artesunate 226, all negative. Control (placebo group) assessment of 179 people, the positive rate of 14.5%. There was no one case of acute schistosomiasis in the medication group, and 3 cases in the control group. After inquiring about 5 40 0 people, the incidence of side effects in 0 .4% or less; no difference with the control group. After taking the hematuria routine, liver and kidney function and ECG review in the normal range, no difference compared with the control group.