论文部分内容阅读
建立了一种新的保护的二糖半乳吡喃糖基(α1→2)葡萄吡喃糖苷的合成方法。甲基-4,6-O-苄叉基-β-D-葡萄吡喃糖苷(1)经区域选择性地苯甲酰化,得到受体甲基-3-O-苯甲酰基-4,6-O-苄叉基-β-D-葡萄吡喃糖苷(2)。该受体与供体异丙基-2-O-苯甲酰基-3-O-烯丙基-4,6-O-苄叉基-β-D-1-硫代半乳吡喃糖苷(4)偶联,获得了一种保护的二糖Galp(α1→2)Glcp片段甲基-2-O-苯甲酰基-3-O-烯丙基-4,6-O-苄叉基-α-D-半乳吡喃糖基-(1→2)-3-O-苯甲酰基-4,6-O-苄叉基-β-D-葡萄吡喃糖苷(5)。所有的产品通过NMR、MS等方法进行了结构表征。
A new method for the synthesis of the protected disaccharide galactopyranosyl (α1 → 2) glucopyranoside was established. Methyl-4,6-O-benzylidene-β-D-glucopyranoside (1) is selectively benzoylated to provide the methyl-3-O-benzoyl-4, 6-O-benzylidene-β-D-glucopyranoside (2). This receptor binds to the donor isopropyl-2-O-benzoyl-3-O-allyl-4,6-O-benzylidene-β-D-1-thiogalactopyranoside 4) to obtain a protected disaccharide Galp (α1 → 2) Glcp fragment Methyl-2-O-benzoyl-3-O-allyl-4,6-O-benzylidene- α-D-galactopyranosyl- (1 → 2) -3-O-benzoyl-4,6-O-benzylidene-β-D-glucopyranoside (5). All products were characterized by NMR, MS and other methods.