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目的研究血清中血管内皮生长因子(VEGF)检测在白血病患者发病及缓解过程中的见后变化及其临床意义。方法收集30例急性白血病患者作为观察组,18名健康人作为对照组,应用酶联免疫技术(ELISA法)检测两组血清中VEGF浓度。结果急性白血病患者血清VEGF浓度显著高于正常人组(P<0.05),化疗前血清VEGF水平较对照组和完全缓解组明显升高(P<0.05),而完全缓解组与对照组的血清VEGF水平无显著性差异(P>0.05),其部分复发患者再次出现上述改变。结论急性白血病的发生与发展与血管内皮生长因子水平密切相关。
Objective To study the changes of serum vascular endothelial growth factor (VEGF) in the onset and remission of leukemia patients and its clinical significance. Methods Thirty patients with acute leukemia were selected as observation group and 18 healthy individuals as control group. Serum VEGF concentration was detected by enzyme-linked immunosorbent assay (ELISA). Results Serum levels of VEGF in patients with acute leukemia were significantly higher than those in normal controls (P <0.05). Serum VEGF levels in patients with acute leukemia were significantly higher than those in control and complete remission groups (P <0.05) There was no significant difference between the two groups (P> 0.05), and some recurrences occurred in these patients. Conclusions The occurrence and development of acute leukemia are closely related to the level of vascular endothelial growth factor.