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为探讨扁平疣自体植入疗法疣体脱落的病理及免疫学基础，对反应期疣体进行了常现HE染色（7例）和免疫组织化学标记（6例）。结果显示：病理组织学改变（1）疣体反应区淋巴细胞浸润，同时伴棘细胞水肿、溶解；（2）未见急性炎细胞浸润及坏死细胞残骸，未见单核巨噬细胞聚集及其吞噬现象；（3）真皮层血管扩张充血不明显。免疫学特征（1）反应区浸润的淋巴细胞显示CD45RO＋、CD6＋、CD4＋、CD8＋、CD20-、Mac387－；（2）表皮基底层及反应区见S－100蛋白阳性的郎格罕细胞。表明扁平疣脱落的病理和免疫学基础是T细胞介导的免疫反应，主要是CD8＋亚群参与的细胞毒作用，疣体的脱落是由于CD8＋对靶细胞直接杀伤，使细胞溶解坏死所致；表皮内S－100蛋白的郎格罕细胞充当抗原递呈细胞。
In order to investigate the pathological and immunological basis of wart removal by self-implantation therapy of flat warts, HE staining (7 cases) and immunohistochemistry (6 cases) were routinely performed on the wart during the reaction period. The results showed that: (1) lymphocyte infiltration in wart reaction zone accompanied with edema and dissolution of spleen cells; (2) no infiltration of acute inflammatory cells and necrotic cell debris, no accumulation of monocyte-macrophage Phagocytosis phenomenon; (3) dermal vasodilation congestion is not obvious. Immunological Characteristics (1) Lymphocytes infiltrated in the reaction zone showed CD45RO +, CD6 +, CD4 +, CD8 +, CD20- and Mac387-; (2) Squamous cell carcinoma cells with positive S-100 protein in the basal and reaction zone of the epidermis. The results showed that the pathological and immunological basis of shedding of verruca plana was T cell mediated immune response, mainly the cytotoxic effect of CD8 + subsets. The shedding of wart was caused by the direct killing of target cells by CD8 + and the cell lysis and necrosis. Langerhans cells of intrasclear S-100 protein serve as antigen presenting cells.