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库欣综合征又称皮质醇增多症,是一组因下丘脑-垂体-肾上腺轴调控失常,肾上腺皮质分泌过多糖皮质激素所致的临床综合征。该病患者临床常表现为向心性肥胖、满月脸、多血质外貌、紫纹、高血压、继发性糖尿病和骨质疏松等症状。库欣综合征可发生于任何年龄,但20~45岁多发,成人多于儿童,女性多于男性,男女比例为1∶3~1∶8[1-2]。库欣综合征按其病因可分为促肾上腺皮质激素(adrenocorticotrophic hormone,ACTH)依赖性和非依赖性两大类。其中80%~85%患者的皮质醇分泌增多与ACTH有
Cushing’s syndrome, also known as Cushing’s syndrome, is a group of clinical syndromes caused by dysregulation of the hypothalamus-pituitary-adrenal axis and excessive glucocorticoid secretion by the adrenal cortex. The patient’s clinical manifestations are often centripetal obesity, full moon face, multiple blood appearance, purple pattern, hypertension, secondary diabetes and osteoporosis and other symptoms. Cushing’s syndrome can occur at any age, but more than 20 to 45 years old, more adults than children, more women than men, male to female ratio of 1: 3 to 1: 8 [1-2]. Cushing’s syndrome can be divided into adrenocorticotrophic hormone (ACTH) dependent and non-dependent two major categories according to their causes. 80% to 85% of patients with increased cortisol and ACTH have