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目的：应用黄斑区密集点矩阵视野（ｄｅｎｓｅｍａｔｒｉｘｍａｐｐｉｎｇｉｎｍａｃｕｌａ，ＤＭＭＭ）探讨老年性黄斑变性（ａｇｅ－ｒｅｌａｔｅｄｍａｃｕｌａｒｄｅｇｅｎｅｒａｔｉｏｎ，ＡＭＤ）视功能变化及评价其在ＡＭＤ早期诊断中的应用价值。方法：用Ｈｕｍｐｈｒｅｙ－６４０视野计自行设计ＤＭＭＭ检测正常对照组１６人２４只眼，ＡＭＤ干性组５１例７１只眼，湿性组２３例２７只眼。结果：①黄斑区２．５°内ＤＭＭＭ各组平均光敏感度阈值（ｍｅａｎｌｉｇｈｔｓｅｎｓｉｔｉｖｉｔｙ，ＭＬＳ）：ＡＭＤ干性组３３．３０±２．４９，湿性组２０．６７±８．３０，正常老年人组３５．６１±１．３７，组间ｔ检验均有高度显著差异。②黄斑区５°内ＭＬＳ：ＡＭＤ干性组３２．９５±１．８２，湿性组２２．１１±７．７４，正常老年人组３４．９３±１．４６，组间ｔ检验，均有高度显著差异。结论：ＡＭＤ干性组早期便有ＤＭＭＭ的ＭＬＳ改变。ＤＭＭＭ评价ＡＭＤ视功能早期改变的敏感性较高。
OBJECTIVE: To investigate the changes of visual function in patients with age-related macular degeneration (AMD) by using densematrixmappinginmacula (DMMM) and to evaluate its value in the early diagnosis of AMD. Methods: DMMM was designed by Humphrey-640 to measure 16 eyes in 16 eyes of normal control group, AMD dry group 51 eyes 71 eyes, wet eyes 23 eyes 27 eyes. Results: ①The average light sensitivity (MLS) of each DMMM group within 2.5 ° of macular area was 33.30 ± 2.49 in AMD dry group, 20.67 ± 8.30 in wet group, 35 in normal group .61 ± 1.37, t test between groups were highly significant differences. ② MLS in 5 ° macular area: 32.95 ± 1.82 in AMD dry group, 22.11 ± 7.74 in wet group and 34.93 ± 1.46 in normal control group Significant differences. Conclusions: The DMMM MLS changes early in the AMD dry group. The DMMM evaluates the higher sensitivity of early changes in AMD visual function.