传递体递药系统的研究进展

• 作 者: 梁易 张志荣
• 机 构: 四川大学华西药学院,靶向药物与释药系统教育部重点实验室,（成都,610041）
• 出 处: 四川大学学报（医学版）
• 发表日期: 2021年4期
• 关键词: 传递体 变形性 表面活性剂 处方工艺 经皮给药 口服给药

传递体是一种类脂质的新型给药载体，具有优良的变形性、压差渗透性、两亲性等特点，主要在经皮给药和口服给药领域有较多应用，但传递体的处方组成使其对于静脉注射等全身给药途径的稳定性和有效性有待考量，或可通过处方的增加和改良以扬长避短，未来传递体凭借其变形性，或可在生理屏障（如血脑屏障等）的透过、在经皮免疫的疫苗研发等方面显示出其独特的优势。本文对传递体在主要性质、处方工艺因素、评价方法、主要给药途径及问题等方面进行了概述、例证和探讨，对传递体研究的思路加以归纳，对其研究前景予以展望。“,”The transformersome is a new kind of lipoid drug delivery carrier. It has a number of excellent properties, including deformability, pressure permeability, and amphiphilicity. It has been widely used in the field of percutaneous and oral administration of medication. However, due to factors concerning its formulation, the stability and effectiveness of intravenous injection and other systemic routes of administration of transfersomes should be carefully examined. As an alternative, the formulation can be enhanced or improved in order to better exploit the strengths and avoid the weaknesses. Because of its deformability, transfersome may have distinctive potential strengths in the penetration of physiological barriers, for example, the blood-brain barrier, and in the research and development of transdermal immunization vaccines. This review has summarized five aspects of transfersomes, including the main properties, the formulation and process influencing factors, evaluation methods, main administration routes, and problems. Herein, we have given some examples and analysis, summarized the research achievements and assessd prospects for future development.