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目的研究氟中毒大鼠机体内氟的蓄积情况。方法将20只12周龄的SD大鼠随机分为对照组和氟中毒组,其中对照组8只,氟中毒组12只。氟中毒组每天腹腔注射1.0 g/L NaF(10 ml/kg),对照组每天腹腔注射0.9 g/L NaCl溶液(10 ml/kg),45 d后测定大鼠尿氟和骨氟含量。统计学处理采用POMS 2.0版统计学软件包,组间比较用t检验,P<0.05为差异有统计学意义。结果氟中毒组与对照组相比,骨氟含量显著升高(t=2.8,P=0.012 8);尿氟含量显著升高(t=7.11,P<0.01)。结论氟中毒大鼠机体内有过量氟蓄积。
Objective To study the accumulation of fluoride in the body of fluorosis rats. Methods Twenty SD rats of 12 weeks old were randomly divided into control group and fluorosis group, including 8 in control group and 12 in fluorosis group. The rats in fluorosis group were intraperitoneally injected with 1.0 g / L NaF (10 ml / kg), while the control group were given 0.9 g / L NaCl solution (10 ml / kg) daily. Statistical analysis using POMS version 2.0 statistical software package, t test between groups, P <0.05 was considered statistically significant. Results Compared with the control group, the fluoride content in the fluorosis group was significantly increased (t = 2.8, P = 0.012 8). The urinary fluoride content was significantly increased (t = 7.11, P <0.01). Conclusion There is excessive fluoride accumulation in the body of fluorosis rats.