论文部分内容阅读
目的探讨狼疮肾炎(LN)患者血脂水平的特点及其临床意义。方法回顾性分析比较2006-2013年在本院住院的155例系统性红斑狼疮(SLE)患者的血脂水平,其中,伴狼疮性肾炎者83例为LN组,不伴狼疮性肾炎者72例为non-LN-SLE组,另抽取门诊健康体检者46人作为健康对照组,分析各组人群肾功能指标与血脂水平特点,并进行相关性分析及多元回归线性分析。结果 LN组与其余两组相比,血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、尿素氮(BUN)、肌酐(Cr)水平明显升高,高密度脂蛋白胆固醇(HDL-C)水平明显降低,差异有统计学意义(P<0.05),BUN、24 h尿蛋白定量(24hU-Pr)与血脂水平明显相关,高TG及低HDL-C是LN患者肾脏损害的危险因素。结论 LN患者容易出现血脂异常,脂质异常与肾功能恶化密切相关,因此,及早对LN患者血脂水平的干预有助于延缓患者肾脏损害的进程。
Objective To investigate the characteristics and clinical significance of blood lipid levels in patients with lupus nephritis (LN). Methods The blood lipid levels of 155 patients with systemic lupus erythematosus (SLE) hospitalized in our hospital from 2006 to 2013 were retrospectively analyzed. Among them, 83 patients with lupus nephritis were LN group, and 72 patients without lupus nephritis 46 non-LN-SLE patients were selected as healthy control group, and the renal function indexes and blood lipid levels of each group were analyzed. Correlation analysis and multiple linear regression analysis were performed. Results Compared with the other two groups, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), blood urea nitrogen (BUN) and creatinine (Cr) HDL-C levels were significantly lower (P <0.05), BUN, 24-h urinary protein (24hU-Pr) levels were significantly correlated with blood lipid levels, high TG and low HDL-C Is a risk factor for kidney damage in LN patients. Conclusion LN patients are prone to dyslipidemia and lipid abnormalities are closely related to the deterioration of renal function. Therefore, the early intervention of serum lipids in patients with LN may help to delay the progression of renal damage in patients.