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为使患重度中性白细胞减少症的患者减少被细菌感染的危险,往往需给予预防性抗生素治疗(如氟喹诺酮类),称之肠道的选择性净化,但其缺点是最终会导致抗生素耐药性的产生。本文作者发现在荷兰一家医院的血液病房里,从1996年～1999年,耐环丙沙星阴沟肠杆菌和大肠杆菌的发生率分别从<0.5％上升到20.7％及从<0.5％到64％。该院从1998年11月至1999年10月所分离的菌株,环丙沙星对其的MIC为>2mg/mL。根据微扫描步查(walk-A-way)系统得到的常规抗生素耐药谱对所有耐环丙沙星菌株的分类鉴定,以及用琼脂稀释法测定细菌对环丙沙星、头孢他啶、庆大霉素、妥布霉素、阿米卡
In order to reduce the risk of bacterial infections in patients with severe neutropenia, preventive antibiotic therapy (such as fluoroquinolones), often referred to as selective purification of the intestine, is often detrimental to eventually leading to antibiotic resistance Pharmacological production. The authors found that the incidence of Ciprofloxacin-resistant Enterobacter cloacae and Escherichia coli increased from <0.5% to 20.7% and from <0.5% to 64%, respectively, from 1996 to 1999 in a blood ward at a Dutch hospital . The strain isolated from the hospital from November 1998 to October 1999, ciprofloxacin its MIC> 2mg / mL. All anti-Ciprofloxacin-resistant strains were classified and identified by the conventional antibiotic resistance spectrum obtained by the walk-A-way system and the antibacterial activity of the bacteria against ciprofloxacin, ceftazidime, Su, tobramycin, amikacin