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目的 分析第三代头孢菌素对医院致病菌的耐药性。方法 对我院3年来分离的临床细菌进行细菌培养 ,其中4666株做第三代头孢菌素药敏试验。 结果 发现医院致病菌对第三代头孢菌素的平均耐药率为34.29 % ,其中头孢哌酮 +舒巴坦的耐药率仅为6.89 % ,显著低于平均耐药率 (p<0.01)。不动杆菌属、肠杆菌属、枸橼酸杆菌属和假单孢菌属的耐药率分别为58.83 %、56.35 %、52.00 %和49.83 % ,均显著高于平均耐药率 (p均<0.01) ;沙门菌属和变形杆菌属对第三代头孢菌素仍保持较高的敏感性 ,耐药率仅为6.83 %和7.87 % ;铜绿假单孢菌对头孢哌酮的耐药性高于头孢曲松、头孢噻肟以头孢他啶 ,且呈逐渐上升趋势。结论 使用第三代头孢菌素时 ,宜合用具有良好活性的β-内酰胺酶抑制剂
Objective To analyze the resistance of the third generation cephalosporins to pathogenic bacteria in hospitals. Methods The bacterial culture of clinical bacteria isolated in our hospital for 3 years was carried out. Among them, 4666 strains were used for the third generation cephalosporin susceptibility test. The results showed that the average rate of resistance to third generation cephalosporins in hospital was 34.29%, of which cefoperazone / sulbactam was only 6.89%, which was significantly lower than the average resistance (p <0.01 ). The rates of resistance in Acinetobacter, Enterobacter, Citrobacter and Pseudomonas were 58.83%, 56.35%, 52.00% and 49.83%, respectively, which were significantly higher than the average resistance rates (all p < 0.01). Salmonella and Proteus belonged to the third generation cephalosporins still maintained a high sensitivity, resistance rates were only 6.83% and 7.87%; Pseudomonas aeruginosa cefoperazone resistance is high In ceftriaxone, cefotaxime ceftazidime, and showed a gradual upward trend. Conclusion When using the third generation cephalosporins, we should combine with good activity of β-lactamase inhibitor