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作者将盐酸可卡因溶液加入碳酸氢钠溶液后用乙醚提取,提取物用无水硫酸钠干燥,再加入0.01N 盐酸溶解,以0.01N 盐酸为空白;在233nm 处测吸收度,发现吸收度不受杂质苯酰芽子碱(benzoylecgoni-ne)和芽子碱(ecgonine)的影响并遵守比尔定律。据此,作者观察到盐酸可卡因溶液的水解为假性一级反应,并测定了 pH 在1.00～8.80之间的反应速度常数。已知英国副药典(BPC)中,5%可卡因滴眼剂的处方为未加缓冲剂的溶液。作者测定了该滴眼剂高压灭菌前后的 pH 及含量的变化。结果表明:高压灭菌前pH 为5.8;灭菌后 pH 为3.1,含量为97%;5℃放置3个月后含量为96%,放置6个月为89%;25℃
The authors will be added to the sodium bicarbonate solution of cocaine hydrochloride solution was extracted with ether, the extract was dried over anhydrous sodium sulfate, then add 0.01N hydrochloric acid dissolved 0.01N hydrochloric acid as a blank; measured at 233nm absorbance and found that the absorption is not affected Impacts of benzoylecgoni-ne and ecgonine are observed and Beer’s law is observed. Accordingly, the authors observed that the hydrolysis of the cocaine hydrochloride solution was a pseudo-first-order reaction and the reaction rate constant was measured at a pH between 1.00 and 8.80. Known in the British Pawn Pharmacopoeia (BPC), 5% cocaine eye drops prescription is unbuffered solution. The authors measured the eye drops before and after autoclaving pH and content changes. The results showed that the pH was 5.8 before autoclaving, the pH was 3.1 after sterilization, the content was 97%, the content was 96% after 3 months at 5 ℃ and 89% after 6 months