内毒素对动脉粥样硬化形成的影响

• 作 者: 陈国强 张彤 杨永宗
• 机 构: 衡阳医学院病理生理教研室,衡阳医学院病理生理教研室,衡阳医学院病理生理教研室,
• 出 处: 衡阳医学院学报
• 发表日期: 1991年03期
• 关键词: 内毒素 多因素疾病 endotoxin 胆固醇酯 巨噬细胞 血管内皮细胞 脂血症 动脉粥样硬化 胆固醇 高胆固醇血症

动脉粥样硬化(AS)系一多因素疾病。多种危险因素(如高脂血症,高血压、糖尿病、肥胖等)均可能诱发和促进其形成。基于血管内皮细胞(VEC)损伤是 AS 形成的起始步骤,早在七十年代中、后期就有人根据“内毒素(endotoxin,ET),可引起 VEC 损伤”的事实提出 ET 可能参与 AS 形成。八十年代中期,又有人发现内毒素及其诱导物可促进巨噬细胞内胆固醇酯的合成,并促使胆固醇蓄积于细胞内。据此提出 ET 可能促

Atherosclerosis (AS) is a multifactorial disease. A variety of risk factors (such as hyperlipidemia, hypertension, diabetes, obesity, etc.) may induce and promote its formation. Based on the fact that vascular endothelial cell (VEC) injury is the initial step of AS formation, ET was suggested to be involved in AS formation as early as in the mid-1970s and in the late stage according to the fact that “endotoxin (ET) causes VEC damage”. The mid-eighties, it was also found that endotoxin and its inducer can promote cholesterol ester synthesis in macrophages and promote the accumulation of cholesterol in the cell. Accordingly, ET may promote