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目的 观察THP联合化疗中晚期肺癌的临床疗效及其毒副作用。方法 在CAP方案中,用THP替代ADM组成的CTP方案治疗中晚期肺癌30例,同时用以ADM组成的CAP方案治疗中晚期肺癌可入组者30例,进行随机对照。结果 THP与ADM总有效率分别为46.7％和40.0％,毒副反应主要为骨髓抑制和胃肠道反应。两者比较,脱发和心脏毒性THP明显低于ADM(P<0.01)。结论 THP与ADM疗效相当,且毒副反应尤其心脏毒性明显降低,为CTP方案的广泛应用创造了条件。
Objective To observe the clinical efficacy and side effects of advanced lung cancer with THP combined with chemotherapy. Methods In the CAP protocol, 30 patients with advanced lung cancer were treated with THP instead of ADM, 30 patients with advanced lung cancer were treated with the CAP regimen consisting of ADM, and randomized control was performed. Results The total effective rates of THP and ADM were 46.7% and 40.0% respectively. The toxicity was mainly myelosuppression and gastrointestinal reactions. Comparing the two, hair loss and cardiac toxicity were significantly lower than those of ADM (P<0.01). Conclusion THP and ADM have similar efficacy, and toxic side effects, especially cardiac toxicity, are significantly reduced, which creates the conditions for the wide application of CTP.