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目的 了解慢性HBV感染者血清β_2-MG的水平及其临床意义。方法 采用放射免疫法(RIA)对142例慢性HBV感染者[其中慢性无症状携带者(ASC)21例,慢性肝炎轻度(CmiH)47例,慢性肝炎中度(CmoH)50例,慢性肝炎重度(CseH)16例,肝炎肝硬变(LC)8例]进行血清β_2-MG的检测,并同时检测30例正常人作为对照。结果 血清β_2-MG水平在CseH、CmoH、LC、CmiH、ASC、和正常对照组依次为4.16±1.02、3.19±0.71、2.69±0.60、2.02±0.55、1.56±0.67、2.05±0.55mg/L。ASC组明显低于正常对照组,而CmiH、CmoH、CseH和LC组均明显高于正常对照组(P值均<0.01)。结论 慢性HBV感染者血清β_2-MG水平与肝脏病变的活动程度有关。
Objective To investigate the serum level of β_2-MG in patients with chronic HBV infection and its clinical significance. Methods Radioimmunoassay (RIA) was used to screen 142 patients with chronic HBV infection [including 21 cases of chronic asymptomatic carriers (ASC), 47 cases of chronic mild hepatitis (CmiH), 50 cases of chronic hepatitis C (CmoH) Serum β_2-MG was detected in 16 cases of severe CseH and 8 cases of cirrhosis of liver. 30 normal subjects were also detected as controls. Results Serum β_2-MG levels were 4.16 ± 1.02,3.19 ± 0.71,2.69 ± 0.60,2.02 ± 0.55,1.56 ± 0.67,2.05 ± 0.55mg / L in CseH, CmoH, LC, CmiH, ASC and normal control group. The level of CmiH, CmoH, CseH and LC in the ASC group was significantly lower than that in the normal control group (all P <0.01). Conclusion The serum level of β_2-MG in patients with chronic HBV infection is related to the degree of liver disease.