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引发白血病的基因与引起另一组疾病的基因存在重叠,这些疾病就是,骨髓要么无法产生健康的血细胞,要么产生大量错误类型的血细胞。这些状况中最为严重的就是一种非侵蚀性癌症——骨髓增生异常综合症(MDS)。大约1/3的骨髓增生异常综合症患者都会发展为急性髓系白血病,而这些患者都没有良好的预后。若能更好地了解MDS的基因,或许不仅可以提高其诊断率,同时对预测骨髓增生异常综合症向急性髓系白血病转化亦有所帮助。牵涉到急性髓系白血病的很多基因,同样出现在MDS病例中。研究人员发现,MDS病
The gene that causes leukemia overlaps with the gene that causes another group of diseases, the bone marrow either failing to produce healthy blood cells or producing a large number of erroneous types of blood cells. The most serious of these conditions is a non-aggressive cancer, myelodysplastic syndrome (MDS). About one-third of patients with myelodysplastic syndrome develop acute myeloid leukemia, and none of these patients have a good prognosis. A better understanding of the genes involved in MDS may not only improve its diagnostic yield, but also predict the conversion of myelodysplastic syndromes to acute myeloid leukemia. Many genes involved in acute myeloid leukemia also appear in MDS cases. Researchers found that MDS disease