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目的临床观察奥美拉唑与阿莫西林和甲硝唑三联法治疗幽门螺旋杆菌阳性胃溃疡的临床疗效。方法选取行电子胃镜操作检查确诊为胃溃疡伴幽门螺旋杆菌阳性者96例,随机分为2组,各48例。对照组采用口服雷尼替丁,治疗组给予口服奥美拉唑、阿莫西林与甲硝唑。观察每位患者治疗前后的症状、体征、溃疡情况及生化指标,并评价疗效。结果经过8周治疗后的患者,对照组和治疗组患者上述指标均有显著改善,镜检胃和十二指肠粘膜明显修复,幽门螺旋杆菌呈阴率,治疗前后相比较有统计学差异(P<0.05)。治疗组治疗后总有效率为95.8%,对照组为77.1%,差异有统计学意义(P<0.05)。结论奥美拉唑联合阿莫西林和甲硝唑治疗胃溃疡有显著的临床疗效,幽门螺旋杆菌转阴率高,临床症状消失,无明显不良反应且经济实惠,值得基层卫生院借鉴和推广。
Objective To observe the clinical efficacy of omeprazole combined with amoxicillin and metronidazole in the treatment of Helicobacter pylori positive gastric ulcer. Methods Ninety-six patients with gastric ulcer associated with Helicobacter pylori diagnosed by electronic gastroscopy were randomly divided into 2 groups (n = 48 in each group). The control group was given oral ranitidine, and the treatment group was orally given omeprazole, amoxicillin and metronidazole. Before and after treatment for each patient observed symptoms, signs, ulcers and biochemical indicators, and evaluate the efficacy. Results After 8 weeks of treatment, the above indexes of the control group and the treatment group were significantly improved, the gastric mucosa of the stomach and duodenum were obviously repaired, and the H. pylori was negative, with statistical difference before and after treatment P <0.05). After treatment, the total effective rate was 95.8% in the treatment group and 77.1% in the control group, the difference was statistically significant (P <0.05). Conclusion omeprazole combined with amoxicillin and metronidazole in the treatment of gastric ulcer have a significant clinical effect, Helicobacter pylori negative conversion rate, clinical symptoms disappear, no obvious adverse reactions and economical, it is worth grass-roots hospitals to learn and promote.