论文部分内容阅读
舒林酸有明显的抗炎、镇痛、解热作用。灌胃给药使巴豆油致小鼠耳廓肿胀、角叉菜胶致大鼠足跖肿胀抑制２５％的半数有效量（ＥＤ５０）分别为３６±５６和１４±５ｍｇ／ｋｇ，２０和４０ｍｇ／（ｋｇ·ｄ）或连续５ｄ对棉球肉芽肿和佐剂性关节炎也有显著抑制作用。镇痛试验：小鼠热板法和醋酸扭体法测得ＥＤ５０分别为４６±１９和５２±１１ｍｇ／ｋｇ；使酵母致热大鼠降低１℃的ＥＤ５０为６．２±２．５ｍｇ／ｋｇ；使大鼠试验群５０％致胃出血的半数致溃疡量（ＵＤ５０）为５６±１２ｍｇ／ｋｇ。
Sulindac has obvious anti-inflammatory, analgesic, antipyretic effect. Administration of gavage resulted in swelling of the auricles of mice caused by croton oil, carrageenan induced rat paw edema inhibition of 25% of the half effective dose (ED50) were 36 ± 56 and 14 ± 5mg / kg, 20 and 40mg / (Kg · d) or continuous 5d on cotton granuloma and adjuvant arthritis also had a significant inhibitory effect. Analgesic test: The ED50 was 46 ± 19 and 52 ± 11 mg / kg for the mouse hot plate method and the acetic acid writhing method, respectively. The ED50 for lowering the temperature of the yeast pyrogenic strain by 1 ° C was 6.2 ± 2.5 mg / kg ; 50% of the rat experimental group caused by gastric ulcer half the amount of ulcer (UD50) of 56 ± 12mg / kg.