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目的探讨职业性慢性镉中毒的临床表现及尿镉、尿β2微球蛋白、尿视黄醇结合蛋白治疗前后的比较,为及时控制病情的预后提供依据。方法回顾分析本院收治96例患者的临床资料,按照《职业性镉中毒诊断标准》GBZ17-2002进行职业病诊断,并对各项结果进行综合分析。结果职业性慢性轻度镉中毒常见的临床表现为乏力、头晕、腰痛、四肢痛;给予积极对症治疗后,尿镉有所下降,尿β2微球蛋白和尿视黄醇结合蛋白下降明显。尿视黄醇结合蛋白排出增加较β2微球蛋白更为明显,泌尿系结石患病率增高,血钙降低。结论尿镉高低与尿2β微球蛋白、尿视黄醇结合蛋白的数值大小并未形成递进的关系,在治疗上,仍以对症支持治疗为主。
Objective To investigate the clinical manifestations of occupational chronic cadmium poisoning and urinary cadmium, urine β2 microglobulin, urinary retinol binding protein before and after treatment compared to provide the basis for timely control of the prognosis of the disease. Methods The clinical data of 96 patients admitted to our hospital were retrospectively analyzed. Occupational disease was diagnosed according to the diagnostic criteria of occupational cadmium poisoning GBZ17-2002, and the results were comprehensively analyzed. Results The common clinical manifestations of occupational chronic mild cadmium poisoning were fatigue, dizziness, low back pain and extremities pain. After positive symptomatic treatment, the urinary cadmium decreased and the urinary β2 microglobulin and urinal retinol binding protein decreased significantly. Urine retinol binding protein increased more pronounced than β2 microglobulin, urinary tract stones increased prevalence, decreased serum calcium. Conclusion The urinary cadmium level does not form a progressive relationship with the urinary 2β microglobulin and urinary retinol binding protein. In treatment, the supportive symptomatic treatment is still the mainstay.