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探讨大鼠海马结构缺血再灌注损伤机理及绞股蓝皂甙抗缺血再灌注损伤的作用。结果：ＩＲ组海马组织中ＭＤＡ含量高于ＳＯＣ组（Ｐ＜０．０１），而ＳＯＤ含量低于ＳＯＣ组（Ｐ＜０．０１），差异非常显著；ＩＲ＋ＧＰ组海马组织中ＭＤＡ含量明显低于ＩＲ组（Ｐ＜０．０１），而ＳＯＣ含量明显高于ＩＲ组（Ｐ＜０．０１），ＩＲ组海马组织Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ，Ｃａ２＋－ＡＴＰａｓｅ的活性明显低于ＳＯＣ组（Ｐ＜０．０１），ＩＲ＋ＧＰ组Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－ＡＴＰａｓｅ活性基本恢复。同时电镀观察神经组织的损害也有明显差异。提示绞股蓝总皂甙能提高ＳＯＣ的活力，减少脂质过氧化物的生成，减轻海马结构缺血再灌注损伤。其作用机理与抗氧化作用，改善ＡＴＰ酶的功能有关。
To investigate the mechanism of hippocampal ischemia-reperfusion injury in rats and the effect of gypenosides against ischemia-reperfusion injury. Results: The content of MDA in hippocampus tissue of IR group was higher than that of SOC group (P<0.01), but the content of SOD was lower than that of SOC group (P<0.01). The difference was very significant; the content of MDA in hippocampus of IR+GP group was significantly lower than that of SOC group. In the IR group (P<0.01), the SOC content was significantly higher than that in the IR group (P<0.01). The activity of Na+-K+-ATPase and Ca2+-ATPase in the hippocampus of the IR group was significantly lower than that of the SOC group (P<0). .01), The activity of Na+-K+-ATPase and Ca2+-ATPase in IR+GP group basically recovered. At the same time electroplating to observe the damage of nerve tissue is also significantly different. It is suggested that Gynostemma total saponin can increase the activity of SOC, reduce the production of lipid peroxide, and reduce the ischemia-reperfusion injury of hippocampal formation. Its mechanism of action is related to its anti-oxidation and improvement of ATPase function.