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目的探讨凝血因子Ⅶ、Ⅷ在2型糖尿病合并肝损害患者中的表达及临床意义。方法应用酶联免疫吸附试验(ELISA)测定30例初发单纯糖尿病患者、30例糖尿病合并肝损害患者、30例其他原因造成的肝损害患者血清中凝血因子Ⅶ、Ⅷ表达水平,并与30例正常对照组比较。结果糖尿病合并肝损害组中凝血因子Ⅶ、Ⅷ表达均高于正常对照组、单纯糖尿病组、其他原因造成的肝损害组,差异有统计学意义(P<0.05);单纯糖尿病组、其他原因造成的肝损害与正常对照组比较,差异无统计学意义(P>0.05);单纯糖尿病组与其他原因造成的肝损害组相比较,差异无统计学意义(P>0.05)。结论糖尿病患者凝血因子Ⅶ、Ⅷ的表达在疾病的进展、病情评估及治疗中均具有重要的临床价值。
Objective To investigate the expression and clinical significance of coagulation factors Ⅶ and Ⅷ in type 2 diabetic patients with liver damage. Methods Serum levels of coagulation factors Ⅶ and Ⅷ were measured in 30 patients with newly diagnosed diabetes mellitus and 30 patients with diabetes mellitus and liver damage caused by other causes in 30 patients by enzyme-linked immunosorbent assay (ELISA) Comparison of normal control group. Results The expression of coagulation factors Ⅶ and Ⅷ in diabetic patients with liver damage were significantly higher than those in normal control group, simple diabetic group and other causes of liver damage (P <0.05). In simple diabetic group, other causes (P> 0.05). There was no significant difference in liver damage between the simple diabetic group and other groups (P> 0.05). Conclusion The expression of coagulation factors Ⅶ and Ⅷ in patients with diabetes mellitus has important clinical value in disease progression, disease evaluation and treatment.