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目的 探讨癌基因HS-1相关蛋白X-1(HAX-1)在乳腺癌中的表达及其与乳腺癌临床病理特征的关系.方法 收集88例乳腺癌及癌旁组织,采用免疫组织化学法检测HAX-1在乳腺癌及癌旁组织中的表达,并与增殖细胞核抗原Ki67的表达比较,分析HAX-1与乳腺癌进展的相关性.结果 乳腺癌中HAX-1及Ki67的表达高于癌旁组织(P<0.05).乳腺癌分化程度低、有淋巴结转移及雌激素受体阴性患者HAX-1、Ki67均为高表达(P<0.05).HAX-1和Ki67的表达呈正相关(r2=0.56,P<0.01).结论 HAX-1是乳腺癌相关基因,可能在乳腺癌的侵润和转移中起重要作用.“,”Objective To inestigate the expression of oncogene HAX-1 in breast carcinoma and its relationship with clinicopathological features .Methods The expressions of HAX-1 gene were detected by immunohistochemical analysis in 88 human breast carcinoma samples and the tumor-adjacent normal tissues ,which were compared with those of cell proliferative factor Ki67 .The relationship of HAX-1 expression with clinicopathological features was analyzed .Results The HAX-1 and Ki67 were highly expressed in breast carcinoma tissues than those in the tumor-adjacent normal tissues(P<0 .05) .The HAX-1 and Ki67 were highly expressed in the breast cacer patients with low differentiation ,lymph node metastasis and estrogen receptor negative (P<0 .05) .The expression of HAX-1 in breast cancer was positively correlated with that of Ki67(r2 =0 .56 ,P<0 .01) .Conclusion HAX-1 is a breast cancer-associated gene and may play an important role in the invasion and metastasis of breast cancer .