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双氯灭痛缓释栓(SR-Supp)在临床上可减轻病人睡眠期的疼痛,有助于减少焦虑。制备方法把卵磷脂350 mg(天然大豆磷脂或氢化大豆磷脂)溶于80℃的甘油三酸酯基质650 mg内,然后把双氯灭痛50 mg溶于50℃的基质950 mg内,在熔融状态下,注入塑模中,在室温下固化制成SR-Supp。采用Higuchi的过滤型仪器进行SR-Supps中主药的溶出试验,该仪器的机理基于直肠液渗透基质的速率,能控制栓剂中主
Diclofenac sustained release suppository (SR-Supp) can reduce the pain of patients during sleep and help reduce anxiety. Method of preparation Lecithin 350 mg (natural soy lecithin or hydrogenated soya lecithin) was dissolved in 650 mg of triglyceride matrix at 80 ° C and 50 mg of diclofenac was dissolved in 950 mg of matrix at 50 ° C. In the molten state, Injected into the mold and cured at room temperature to make SR-Supp. The dissolution test of the main drug in SR-Supps was performed using Higuchi’s filter-type instrument whose mechanism was based on the rate of rectal fluid penetration into the matrix and was able to control the suppository’s main