论文部分内容阅读
目的对某蓄电池企业作业工人的血铅进行检测,初步观察口服金属硫蛋白(MT)后血铅浓度的变化,并对结果进行分析,探讨对作业工人铅中毒的前期干预方法。方法对该蓄电池企业作业工人39名抽取静脉血测定血铅,并随机将金属硫蛋白制剂和模拟金属硫蛋白制剂分发给39名作业工人口服一周期后,重新测定血铅值。结果实验前31份血铅检测结果中最大值为2.75μmol/L,平均值为1.93μmol/L,中位数为1.87μmol/L;实验中对照组口服前、后的检测值,经配对t检验,n=16,α=0.05,t=0.9360.05;实验组口服MT前、后的检测值,经配对t检验,n=14,α=0.05,t=9.211>t0.05,14=2.145,P<0.05。提示蓄电池厂的作业工人血铅水平较高;口服了金属硫蛋白的实验组与口服了模拟金属硫蛋白的对照组血铅下降值的总体均数不等。结论提示金属硫蛋白可用于铅作业工人铅中毒的前期干预。
Objective To detect the blood lead level of workers in a battery enterprise and to observe the change of blood lead level after oral administration of metallothionein (MT). The results were analyzed to discuss the pre-intervention method of lead poisoning for workers. Methods Blood lead levels were measured in 39 venous blood samples of workers in this battery enterprise and 39 workers were randomly assigned to one week for oral administration of metallothionein preparations and simulated metallothionein preparations. Results The maximal value of blood lead test was 2.75μmol / L in the 31 blood samples before the experiment, with an average of 1.93μmol / L and a median of 1.87μmol / L. In the control group, the values before and after oral administration were paired with t Test, n = 16, α = 0.05, t = 0.936 0.05; test group before and after oral administration of MT, by paired t test, n = 14, t = 9.211> t0.05, 14 = 2.145, P <0.05. Suggesting that the blood lead levels of workers in battery factories were higher. The overall mean of blood lead values in the experimental group orally administered metallothionein and the control group administered with simulated metallothionein varied. Conclusions suggest that metallothionein can be used for pre-intervention of lead workers in lead poisoning.