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155例研究对象,分为正常组,糖尿病组高血压组(轻中度)。采用TM-2421动态血压监测仪监测记录24小时ABP。结果:(1)三组ABP均呈勺型变化,糖尿病和高血压组SBP水平显著高于正常组(P<0.01,P<0.05)。高血压组DBP水平显著高于正常组和糖尿病组(P<0.01,或P<0.05)。余弦法证实三组ABP变化的显著昼夜节律性,糖尿病和高血压组的夜间血压(SBP、DBP)下降率明显低于正常组(P<0.01,或P<0.05)。(2)ABP参数:糖尿病和高血压组ABP均值和负荷明显高于正常组(P<0.01,或P<0.05);ABP变异性三组之间无显著性差异;高血压组ABP曲线下面积显著性高于正常组(P<0.01),与糖尿病组无显著性差别。结论:高血压和临床正常血压的糖尿病患者均出现ABP部分参数与正常对照组的显著性差异,提示:糖尿病患者在临床明确诊断高血压前已发生血压调节的明显改变。
155 subjects, divided into normal group, diabetic hypertensive group (mild to moderate). Monitor 24-hour ABP with TM-2421 ambulatory blood pressure monitor. Results: (1) The ABP of three groups changed in a spoonful manner. The SBP level in diabetes and hypertension group was significantly higher than that in normal group (P <0.01, P <0.05). DBP levels in hypertension group were significantly higher than those in normal group and diabetes group (P <0.01, P <0.05). The cosine method confirmed significant circadian rhythms of ABP changes in three groups, and decreased rate of nocturnal blood pressure (SBP, DBP) in diabetes and hypertension group was significantly lower than that in normal group (P <0.01 or P <0.05). (2) ABP parameters: mean and load of ABP in diabetes and hypertension group were significantly higher than those in normal group (P <0.01 or P <0.05); there was no significant difference in ABP variability between the three groups; Significantly higher than the normal group (P <0.01), and no significant difference between the diabetic group. Conclusion: There are significant differences between ABP parameters and normal controls in patients with diabetes mellitus and hypertension with normal blood pressure, suggesting that there is a significant change of blood pressure regulation in patients with diabetes before the definite diagnosis of hypertension.