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目的比较研究雷贝拉唑与奥美拉唑联合阿莫西林、克拉霉素三联短期疗法根除幽门螺旋杆菌感染引起的相关消化性溃疡的疗效。方法将2009～2011年我院收治的50例经电子胃镜检查确诊为胃溃疡或十二指肠球部溃疡,并且经快呋塞米素酶试验确定为HP阳性的患者,随机分成治疗组和对照组。治疗组(25例):采用雷贝拉唑,阿莫西林、克拉霉素治疗。对照组(25例):采用奥美拉唑,阿莫西林、克拉霉素治疗。于疗程结束后第五周复查胃镜及检测HP,观察溃疡愈合情况及HP根除情况。结果 50例均完成治疗方案,治疗组溃疡愈合率和HP根除率分别为92%和88%,对照组溃疡愈合率和HP根除率分别为72%和80%,两组愈合率比较有统计学意义(P<0.05);两组幽门螺杆菌根除率比较无统计学差异(P>0.05)。结论以雷贝拉唑为基础的三联疗法对消化性溃疡具有很高的溃疡愈合率和HP根除率,能有效的缓解症状、抑制胃酸的分泌,效价比优于其他质子泵抑制剂。
Objective To compare the curative effect of rabeprazole with omeprazole combined with amoxicillin and clarithromycin triple short-term therapy in eradicating the associated peptic ulcer caused by Helicobacter pylori infection. Methods Fifty patients admitted to our hospital from 2009 to 2011 were diagnosed as gastric ulcer or duodenal ulcer by electron gastroscopy and were divided into treatment group and control group Control group. Treatment group (n = 25): Treatment with rabeprazole, amoxicillin, clarithromycin. Control group (25 cases): Omeprazole, amoxicillin, clarithromycin treatment. In the fifth week after the end of the course of examination gastroscopy and detection of HP, observed ulcer healing and HP eradication. Results All the 50 patients completed the treatment. The ulcer healing rate and HP eradication rate in the treatment group were 92% and 88% respectively. The ulcer healing rate and HP eradication rate in the control group were 72% and 80%, respectively. The healing rate of the two groups was statistically significant (P <0.05). There was no significant difference between the two groups in the eradication rate of Helicobacter pylori (P> 0.05). Conclusion The triple therapy with rabeprazole has a high ulcer healing rate and HP eradication rate for peptic ulcer, which can effectively relieve symptoms and inhibit gastric acid secretion, and its potency ratio is superior to other proton pump inhibitors.