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目的 探讨消萎灵Ⅰ号胶囊治疗慢性萎缩性胃炎及胃癌前病变的作用机制。方法 78例慢性萎缩性胃炎及胃癌前病变患者 ,随机分为 2组。治疗组 5 2例用消萎灵Ⅰ号胶囊治疗 ,对照组 2 6例予维酶素片治疗。 2组疗程均为 3个月。观察 2组治疗前后血液流变学、细胞流变学变化。结果 治疗组治疗前后比较全血黏度及血浆黏度、红细胞聚集指数、红细胞电泳率明显降低 (P <0 .0 1 ,P <0 .0 5 ) ,红细胞电泳时间明显缩短 (P <0 .0 1 )。治疗后治疗组高、中切全血黏度明显低于对照组 (P <0 .0 1 ) ,红细胞电泳时间亦明显短于对照组 (P <0 .0 1 )。结论 消萎灵Ⅰ号胶囊可能通过明显改善患者血液流变学及细胞流变学的异常状态达到治疗效果
Objective To explore the mechanism of Xiaoweiling I capsule in the treatment of chronic atrophic gastritis and precancerous lesions. Methods 78 patients with chronic atrophic gastritis and precancerous lesions were randomly divided into 2 groups. In the treatment group, 52 patients were treated with Xiaoweiling I capsule, and the control group was treated with vitamin tablets. Both groups were treated for 3 months. The changes of hemorheology and cell rheology before and after treatment in the 2 groups were observed. Results The whole blood viscosity, plasma viscosity, erythrocyte aggregation index and red blood cell electrophoresis rate were significantly decreased in the treatment group before and after treatment (P < 0.01, P <0.05). The electrophoresis time of red blood cells was significantly shorter (P < 0.01). ). After treatment, the viscosity of high and middle cut whole blood in the treatment group was significantly lower than that in the control group (P < 0.01), and the electrophoresis time of red blood cells was also significantly shorter than that in the control group (P < 0.01). Conclusion Xiaoweiling I capsule may achieve therapeutic effect by significantly improving the abnormal state of hemorheology and cellular rheology in patients.