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自细胞介素—1是分子量为17kD的主要由免疫细胞产生的一种细胞因子。一般认为它主要介导非特异性免疫反应和调节免疫系统的功能。但近年来研究发现．IL—1及其受体也存在于中枢神经系统。它做为一种神经递质、神经调质或生长因子参与了中枢神经系统的生理及病理活动变化。本文综述了IL—1在中枢神经系统的生理及病理作用。
Cytokin-1 is a cytokine mainly produced by immune cells with a molecular weight of 17 kD. It is generally believed that it mainly mediates non-specific immune responses and modulates the immune system’s function. However, recent studies have found. IL-1 and its receptors are also found in the central nervous system. It acts as a neurotransmitter, neuromodulator or growth factor involved in the central nervous system physiological and pathological changes. This article reviews the physiological and pathological role of IL-1 in the central nervous system.