【摘 要】
：
Recently,two different chemicals have been matched as ligands with the same G-protein-coupled receptor(GPCR).Double-pairing of OGR 1 family GPCRs with pro-ton
【机 构】
：
Laboratory of Pharmacology and Research Institute of Drug Development College of Pharmacy,Pusan Nati
【出 处】
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Acta Pharmacologica Sinica
论文部分内容阅读
Recently,two different chemicals have been matched as ligands with the same G-protein-coupled receptor(GPCR).Double-pairing of OGR 1 family GPCRs with pro-ton and lysolipid raises several questions.First,whether both are the real ligandsfor the GPCRs.Second,whether modulation ofa GPCR by two chemicals could bepossible.Third,one of the chemicals is proton.Proton-sensing not only is a newaction mode of GPCR activation,but also it could be generalized in other GPCRs.In this review,I’d like to summarize the issue and discuss questions with pharma-cological criteria.
Recently, two different chemicals have been matched as ligands with the same G-protein-coupled receptor (GPCR). Double-pairing of OGR 1 family GPCRs with pro-ton and lysolipid raises several questions. First, whether both are the real ligands for the GPCRs.Second, whether modulation of a GPCR by two chemicals could be be able to.Third, one of the chemicals is proton. Proton-sensing not only is a newaction mode of GPCR activation, but also it could be be generalized in other GPCRs.In this review, I’d like to summarize the issue and discuss questions with pharma-cological criteria.
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