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目的观察祛敏平喘方治疗慢性持续期儿童支气管哮喘临床疗效。方法将78例病例随机分为治疗组(51例)和对照组(27例),治疗组服用中药祛敏平喘方,对照组服用孟鲁司特钠咀嚼片;两组均治疗2个月。观察哮喘控制情况、中医症状改善情况及血IgE水平、白三烯受体1(CysL T1-Receptor)mRNA和调节激活正常T细胞表达和分泌细胞因子(RANTES)表达情况。结果①两组治疗后、治疗后2个月哮喘控制量表积分均较本组治疗前明显提高,差异有统计学意义(P<0.05);组间比较,治疗后2个月积分差异有统计学意义(P<0.05)。②治疗组治疗前后中医证候总积分分别为(11.2±1.4)分、(8.5±1.7)分;组内比较,差异有统计学意义(P<0.05)。对照组治疗前后中医证候总积分分别为(11.7±2.0)分、(10.9±1.5)分;组内比较,差异无统计学意义(P>0.05)。两组治疗后比较,总积分差异有统计学意义(P<0.05)。③治疗组IgE水平及CysL T1-Receptor mRNA表达治疗前后组内比较,差异有统计学意义(P<0.05);对照组仅IgE水平治疗前后组内比较,差异有统计学意义(P<0.05)。组间治疗后比较,IgE水平及CysL T1-Receptor mRNA、RANTES表达差异无统计学意义(P>0.05)。结论祛敏平喘方治疗慢性持续期儿童支气管哮喘疗效良好。
Objective To observe the curative effect of Qimin Pingchuan Decoction on chronic bronchial asthma in children with chronic phase. Methods 78 cases were randomly divided into treatment group (n = 51) and control group (n = 27). The treatment group took Qu Min Ping Chuan Fang and the control group took montelukast sodium chewable tablets. Both groups were treated for 2 months . To observe the control of asthma, the improvement of TCM symptoms and the level of serum IgE, the expression of CysL T1-Receptor mRNA and the regulation of the expression of activated T cells and the expression of RANTES. Results ①In two groups, the score of asthma control scale at 2 months after treatment was significantly higher than that before treatment (P <0.05). There was statistical difference between the two groups after 2 months of treatment Significance (P <0.05). ② The total scores of TCM syndromes in the treatment group before and after treatment were (11.2 ± 1.4) points and (8.5 ± 1.7) points respectively. There were significant differences between the two groups (P <0.05). The total scores of TCM syndrome before and after treatment in the control group were (11.7 ± 2.0) and (10.9 ± 1.5) points, respectively. There was no significant difference between the two groups (P> 0.05). The difference between the two groups after treatment was statistically significant (P <0.05). ③ The level of IgE and the level of CysL T1-Receptor mRNA expression in the treatment group before and after treatment were significantly different (P <0.05); the levels of IgE in the control group before and after treatment were significantly different (P <0.05) . There were no significant differences in IgE level, CysL T1-Receptor mRNA and RANTES expression between the two groups after treatment (P> 0.05). Conclusion Qu Mian Ping Chuan Fang treatment of chronic persistent bronchial asthma in children with good effect.